Q1.i · Physiology of Haematological System

Describe the structure and function of adult hemoglobin.

Describe the structure and function of adult haemoglobin.

Explain the similarities and differences between myoglobin and adult haemoglobin (60% of marks) and their physiologic relevance (40% of marks).

Outline the following with respect to platelets: (a) Formation (15% of marks). (b) Structure (40% of marks). (c) Function (45% of marks).

Outline the formation, structure, and function of the platelet.

Outline the formation, structure and function of the platelet.

(a) With respect to red blood cell production, outline the following: (i) the site (10% of marks). (ii) the stimuli (5% of marks). (iii) the process (15% of marks). (b) With respect to red cell breakdown, outline the following; (i) the usual lifespan in neonates and adults (10% of marks). (ii) the process of red cell aging, degradation and clearance (40% of marks). (iii) the process of haemoglobin breakdown (20% of marks).

Briefly outline the production and fate of Red Blood Cells (RBC) (40% of marks). Describe the breakdown of haemoglobin (Hb) (60% of marks).

Describe the features of a red blood cell that facilitate oxygen transport.

Outline the formation, structure and function of the adult red blood cell.

Describe the structure and function of platelets (50% marks). Outline the pharmacology of clopidogrel (50% marks).

Describe the generation of ATP by mitochondria (50% marks) and outline the processes by which ATP is generated in red blood cells (50% marks).