N1.i · Blood & Plasma Components

Describe the structure and function of adult hemoglobin.

Describe the structure and function of adult haemoglobin.

Explain the similarities and differences between myoglobin and adult haemoglobin (60% of marks) and their physiologic relevance (40% of marks).

Outline the following with respect to platelets: (a) Formation (15% of marks). (b) Structure (40% of marks). (c) Function (45% of marks).

Outline the formation, structure, and function of the platelet.

Outline the formation, structure and function of the platelet.

Describe the features of a red blood cell that facilitate oxygen transport.

Outline the formation, structure and function of the adult red blood cell.

Outline the composition of plasma (50% of marks). Describe the functions of albumin (50% of marks).

List the constituents of plasma and the functions of plasma proteins.

Describe the structure and function of platelets (50% marks). Outline the pharmacology of clopidogrel (50% marks).

Describe the generation of ATP by mitochondria (50% marks) and outline the processes by which ATP is generated in red blood cells (50% marks).

(a) With respect to red blood cell production, outline the following: (i) the site (10% of marks). (ii) the stimuli (5% of marks). (iii) the process (15% of marks). (b) With respect to red cell breakdown, outline the following; (i) the usual lifespan in neonates and adults (10% of marks). (ii) the process of red cell aging, degradation and clearance (40% of marks). (iii) the process of haemoglobin breakdown (20% of marks).

Briefly outline the production and fate of Red Blood Cells (RBC) (40% of marks). Describe the breakdown of haemoglobin (Hb) (60% of marks).

Describe the physiology (50% marks) and pharmacology (50% marks) of albumin.