H6.i · Sedatives & Hypnotics

This viva will examine neuropharmacology. Describe the desirable and undesirable pharmacological properties of ketamine when used to intubate frail elderly people in the ICU?

This viva will assess your knowledge of sedative pharmacology. Describe the pharmaceutics of propofol.

This viva will assess your knowledge on thiopentone pharmacology. Why does thiopentone have a rapid onset of action?

This viva will explore your knowledge of propofol pharmacology. What is in an ampoule or bottle of propofol?

This viva will explore your knowledge of midazolam and the actions of benzodiazepines. What is midazolam? What are some of the effects of midazolam?

This viva will explore your knowledge of GABA (Gamma Amino Butyric Acid) signalling. Can you outline the pharmaceutics of propofol?

This viva will explore the rate of administration on pharmacodynamics of sedative drugs. Would you anticipate a different response to an IV bolus of 100 mg of propofol versus a slow infusion of the same dose over 5 minutes?

This viva will examine the pharmacology of propofol and ketamine. What is the mechanism of action of propofol?

This viva tested knowledge related to cholinergic receptors. The pharmacology of Atropine was specifically discussed. The second part of the viva discussed the pharmacology of propofol including rationale for its use in ICU, contents of the ampoule and adverse effects.

This viva covered cerebral physiology and related pharmacology including factors that influence cerebral blood flow and the related pharmacology of propofol and ketamine.

This viva covered cerebral physiology and related pharmacology including factors that influence cerebral blood flow and the related pharmacology of propofol and ketamine.

This Viva tested knowledge on the pharmacology of propofol. It explored mechanism of action, pharmaceutics, basic pharmacokinetics for bolus dosing and infusions and side effects.

This Viva will examine knowledge of Cerebral Blood Flow. What are the determinants of Cerebral Blood Flow? Subsequent discussion involved physiology of Cerebral Blood Flow, its regulation and the pharmacology of propofol.

This Viva will examine knowledge of the pharmacology of commonly used sedatives and their effects on Respiratory and CNS physiology. List the properties of an ideal sedative drug in Intensive Care? Subsequent discussion involved pharmacology of midazolam, how it compares to haloperidol, an understanding of the term “neuroleptic”, respiratory physiological response to sedation and the principles of the EEG.

This Viva will examine your knowledge of the pharmacokinetics of thiopentone. What factors determine how quickly a patient becomes unconscious with an induction dose of thiopentone? Subsequent questions explored knowledge of serum concentration vs time curves and the information derived from them, volume of distribution (factors that affect it and how it is measured), clearance (definition, calculation, relationship to volume of distribution), elimination (first and zero order) and half-life.