Pharmacopeia

Canonical comparison

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Field TICAGRELOR
Haematology · Haematology · Level 2
 PRASUGREL
Haematology · Haematology · Level 2
Mechanism of action

Allosteric, reversible antagonist at P2Y12-R (an ADP receptor), preventing activation of glycoprotein IIb/IIIa→ prevents platelet crosslinking

Irreversibly binds the P2Y12-R (an ADP receptor), preventing activation of glycoprotein IIb/IIIa→ prevents platelet crosslinking
Absorption

BA=40%

 —
Metabolism

Metabolized by CYP3A4

Prodrug- 1 step metabolism
Less susceptible to CYP polymorphism and CYP inhibition or induction than Clopidogrel
Class Group

Antiplatelet

Antiplatelet
Introduction

ADP Receptor Antagonist - Thienopyridine

ADP Receptor Antagonist - Thienopyridine

Prodrug
Legacy Cicm Level

Level 3

Level 3
Main Action

Platelet inhibition

Platelet inhibition