Core pharmacology

Class Group

Antiplatelet

Legacy Cicm Level

Level 3

Introduction

ADP Receptor Antagonist - Thienopyridine

Prodrug

Main Action

Platelet inhibition

Mechanism of action

Irreversibly binds the P2Y12-R (an ADP receptor), preventing activation of glycoprotein IIb/IIIa→ prevents platelet crosslinking

Metabolism

Prodrug- 1 step metabolism
Less susceptible to CYP polymorphism and CYP inhibition or induction than Clopidogrel