Core pharmacology

Class Group

Antiplatelet

Legacy Cicm Level

Level 3

Introduction

ADP Receptor Antagonist - Thienopyridine

Main Action

Platelet inhibition

Mechanism of action

Allosteric, reversible antagonist at P2Y12-R (an ADP receptor), preventing activation of glycoprotein IIb/IIIa→ prevents platelet crosslinking

Absorption

BA=40%

Metabolism

Metabolized by CYP3A4