O2.ii · Gastrointestinal Pharmacology

Classify the 5HT receptors and give examples of pharmacological agents that affect them (60% of marks). Outline the pharmacology of ondansetron (40% of marks).

Classify anti-emetic agents by describing their mechanism of action and provide examples.

Classify antiemetic drugs and describe their mechanism of action.

Compare and contrast the pharmacology of drugs that alter the pH of gastric fluid

Compare and contrast the pharmacology of drugs that change the pH of gastric fluid.

Classify antiemetic drugs and give an example from each group (60% of marks). Outline the gastrointestinal effects of metoclopramide (40% of marks).

Compare and contrast the pharmacology of ranitidine and omeprazole.

Outline the mechanism of action of drugs commonly used to prevent stress ulceration in intensive care.

(a) Describe the physiological factors that influence gastric emptying (80% of marks). (b) With respect to erythromycin, outline the following: (i) mechanism of action on gastric emptying (10% of marks). (ii) important gastrointestinal and non-gastrointestinal adverse effects (10% of marks).

Describe the physiology of gastric emptying (80% of marks). Outline the gastrointestinal effects of erythromycin (20% of marks)

Describe the neural integration of vomiting, highlighting the site and mechanism of action of antiemetics.

Describe the neural integration of vomiting. (60% of marks) Describe the pharmacology of ondansetron. (40% of marks)