L1.iii · Musculoskeletal System Physiology

(a) Explain the excitation contraction mechanism as it relates to the smooth muscle of the myometrium including a gravid uterus (50% of marks). (b) For each tocolytic agent: salbutamol, nifedipine, magnesium sulphate, provide the following information: (i) List the class (10% of marks) (ii) Provide a dose (10% of marks) (iii) Describe the mechanism of action (20% of marks) (iv) Outline the adverse effects (10% of marks)

Describe the process of excitation-contraction coupling and relaxation in smooth muscle.

Describe the processes of excitation and contraction within a smooth muscle cell (60% of marks). Briefly outline the mechanism by which nitric oxide affects smooth muscle cell activity (40% of marks)