S1.i · Physiology of Immunology and Host Defence

This viva will explore your understanding of immunology. What are the immunological events leading to IgE mediated anaphylaxis?

This Viva tested knowledge of classification and mechanisms of resistance to antibiotics. It then explored the immunology related to anaphylaxis and immunoglobulins.

This Viva tested knowledge of the hypersensitivity reactions. It began by asking about different types of hypersensitivity reactions, sought examples for each and also covered aspects of histamine, histamine receptors and adrenaline. Overall most candidates performed well, with knowledge of histamine and histamine receptors being a consistent area of weakness.

The initial information given to the candidates was – An anaesthetist calls you to request an ICU bed for a patient suffering from spina bifida who has just suffered what is believed to be an adverse reaction shortly after induction of anaesthesia. Classify allergic reactions. In this viva candidates were asked to explain and classify allergic reactions, the pharmacological basis to their treatment (eg what are the mechanisms by which adrenaline is used for anaphylaxis) and to list common agents (latex was commonly overlooked) in ICU practice that are associated with allergic reactions.