Pharmacopeia

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Field PRASUGREL
Haematology · Haematology · Level 2
 TIROFIBAN
Haematology · Haematology · Level 3
Mechanism of action

Irreversibly binds the P2Y12-R (an ADP receptor), preventing activation of glycoprotein IIb/IIIa→ prevents platelet crosslinking

Antagonises the GpIIb/IIIa
receptor, preventing the
binding of fibrinogen and
platelet crosslinking and
aggregation.
Metabolism

Prodrug- 1 step metabolism
Less susceptible to CYP polymorphism and CYP inhibition or induction than Clopidogrel

Limited metabolism in humans.
Excretion —

Excreted in urine and faeces, mostly
unchanged
Half-life —

HL 1.9-2.2 hrs
Adverse Effects Toxicity —

Haemorrhage
Difficulty reversing agent
Dose adjustment in renal impairment
Class Group

Antiplatelet

Antiplatelet
Introduction

ADP Receptor Antagonist - Thienopyridine

Prodrug

GP IIb/IIIA Inhibitor
Legacy Cicm Level

Level 3

Level 3
Main Action

Platelet inhibition

Platelet inhibition