Pharmacopeia
Master Compare
Compare candidate-facing canonical Pharmacopeia fields side by side. Isolated AI-draft proposals are never included.
| Field |
NEURAMINIDASE INHIBITORS
Anti-infectives · Anti-infectives · Level 3
|
AMPHOTERICIN B
Anti-infectives · Anti-infectives · Level 3
|
|---|---|---|
| Mechanism of action | inhibit neurominidase resulting in impaired viral release from infected cells. Neurominidase cleaves the sialic acid on the cell membrane allowing viral budding. |
Polyenes specifically target fungal membranes. They bind ergosterol, which is the principal sterol in fungal membranes as opposed to cholesterol found in host membranes. This interference creates a transmembrane channel and the resultant change in permeability allows leakage of intracellular components |
| Absorption | — | only administered IV |
| Distribution | — | Poor tissue penetration. Negligable CSF or urine penetration. |
| Protein binding | — | Highly protein bound |
| Metabolism | — | Metabolised by the liver |
| Excretion | — | poorly characterized but does not accumulate in renal failure |
| Adverse Effects Toxicity | 1. Psychiatric symptoms |
Dose related nephrotoxicity |
| Antimicrobial Spectrum | — | Broad antifungal cover including candida, Cryptococcus, aspergillus and zygomyces |
| Class Group | Antiviral |
Antifungal |
| Introduction | Oseltamivir and Zanamivir |
Polyene |
| Legacy Cicm Level | Level 3 |
Level 3 |