B3.i · Adverse Drug Reactions

Classify and describe adverse drug reactions with examples of each

What is an adverse drug reaction? Classify (with drug examples) the different types.

Compare and contrast the pharmacodynamics of haloperidol, olanzapine, and quetiapine, relevant to their use in intensive care, using the following headings: a) primary mechanism of action (25% of marks). b) extrapyramidal side effects (15% of marks). c) other receptor mediated effects (30% of marks). d) cardiac toxicity (15% of marks). e) idiosyncratic adverse effects (15% of marks).

Describe the physiological basis of the effects seen in the serotonin syndrome (80% marks). List the classes of drugs that may cause the serotonin syndrome (20% marks).