Syllabus · Current · V5 (2025) · Nervous System including autonomic and pain

H6 · Neuropharmacology

H6.iv · Antidepressants

Official V5 objective
Understand the pharmacology of anti-depressant drugs.
3 SAQ topics 3 SAQ appearances 1 VIVA station

Written examination

SAQ history

3 appearances
Compare and contrast the mechanism of action and side effects of tricyclic antidepressants, selective serotonin reuptake inhibitors and monoamine oxidase inhibitors.
40%
Describe the physiological basis of the effects seen in the serotonin syndrome (80% marks). List the classes of drugs that may cause the serotonin syndrome (20% marks).
70%
Describe the physiological effects and principles of management of a tricyclic antidepressant overdose.
14%

Oral examination

VIVA history

1 station

Sources: objective text from the relevant CICM syllabus; historical SAQ and VIVA wording from CICM examiner reports.