B1.i · Compartment Models

This viva will examine general pharmacology concepts. Define volume of distribution. Using the figure provided, how you would determine the initial Volume of distribution (Vd) following administration of 1500 mg IV of drug X. (Drug plasma concentration vs time graph removed from report)

This VIVA will examine pharmacokinetics. Describe the “single compartment model” of pharmacokinetics. What properties of a drug mean that it can be described by a single compartment model?

This viva will test knowledge of pharmacokinetics and statistics Draw the concentration time curve for an intravenous bolus of fentanyl. At this Viva candidates were asked to draw a concentration – time curve for an intravenous bolus of fentanyl, to label it and describe the information relating to that curve. Candidates were also asked about volume of distribution, half-life and clearance. In the second part to this Viva candidates were shown and asked to describe various types of data, mean and median values, normal distribution and critical evaluation of a study.