Core pharmacology

Class Group

ANTIBIOTIC:
BETA LACTAMASE INHIBITOR

Legacy Cicm Level

Level 3

Introduction

Tazobactam is a beta lactamase inhibitor administered with antibiotics such as piperacillin and ceftolozane to prevent their degradation, resulting in increased efficacy.

Indications Uses

When combined with other antibiotics, a variety of infections, including serious and life-threatening infections may be treated

Chemical Pharmaceutics

penicillanic acid sulfone derivative

Presentation

In vials with Piperacillin (500mg/4g Piperacillin or 250mg/2g) or ceftolozane

Tazobactam shows little antibacterial activity by itself, and for this reason, is generally not administered alone

Main Action

Tazobactam broadens the spectrum of piperacillin and ceftolozane by making them effective against organisms that express beta-lactamase and would normally degrade them.

Mechanism of action

Irreversible inhibition of beta-lactamase enzymes.
In addition, tazobactam may bind covalently to plasmid-mediated and chromosome-mediated beta-lactamase enzymes.

Antimicrobial Spectrum

Tazobactam is predominantly effective against the OHIO-1, SHV-1, and TEM groups of beta-lactamases, but may also inhibit other beta-lactamases.

Adverse Effects Toxicity

• Nausea, vomiting, and diarrhea are frequent manifestations of an overdose.
• Neuromuscular excitability or seizures may also occur with high intravenous doses or renal failure. There is no specific antidote
• Anaphylaxis
Nephrotoxicity