Core pharmacology

Class Group

Antidepressant - Monoamine oxidase inhibitors

Legacy Cicm Level

Level 3

Mechanism of action

Irreversible MAO A and B inhibition leading to accumulation of:
1. Noradrenaline
2. Serotonin
Dopamine

Adverse Effects Toxicity

1. Serotonin
2. Histamine
3. Anticholinergic
4. Anti-alpha
5. Adrenergic

Interacts with other antidepressants, foods high in tyramine (cheese) and sympathomimetic

Absorption

Incomplete data available

Distribution

Incomplete data available

Metabolism

Incomplete data available

Excretion

Renal elimination of metabolites

Half-life

Duration depends on time taken for MAO synthesis