Level 1

Phencyclidine (remember the street drug name PCP) derivative that
produces dissociative anesthesia

Induction of anaesthesia
- Procedural sedation
- Analgesia
- ?Role in management of depression. - Recreational

10, 50 or 100mg/ml

NMDA receptor antagonism
- Inhibits excitatory signaling within CNS
- Also inhibits noradrenaline reuptake in sympathetic nerve terminals

CNS: Causes dissociative anaesthesia
- Hallucinations
- Emergence delirium

CVS: Indirect sympathomimetic
chronotropy, inotrophy and Hypertension
Direct cardiodepressant
 if depletion of NA  hypotension
Resp - Bronchodilation

Increased salivation - Upper airway reflexes intact  laryngospasm - Hypotension if given in shock states - Emergence delirium

A: 20% oral bioavailability

25%

3l/kg

Hepatic metabolism with active
norketamine metabolite

Renal elimination

T1/2a 15 mins, T1/2b
2~3 hours, CSHT 40mins at 5 hours

- 1mg/kg induction dose
- 10~20mg analgesia

Non-Opiate Analgesic

Sedative / Hypnotic