Core pharmacology

Class Group

Anticoagulant Reversal Agents

Legacy Cicm Level

Level 3

Introduction

Monoclonal antibody Fab fragment

Presentation

IV 5g bolus

Mechanism of action

Direct binding to Dabigitran

Adverse Effects Toxicity

Minimal
Headache

Absorption

IV only

Volume of distribution

Vd 9L

Metabolism

Hepatic metabolism

Half-life

T1/2= 1 hour (occasionally require second dose)