Core pharmacology

Class Group

Anticoagulants

Legacy Cicm Level

Not in list
(Historical question)

Introduction

Is a naturally occurring peptide found in leaches saliva with anticoagulant properties
recombinant techniques are used to create drugs in this class

Mechanism of action

is via direct irreversible binding to thrombin Causes a prolongation of bleeding time

Adverse Effects Toxicity

Bleeding

Absorption

administered SC

Excretion

excreted in the urine, dose adjustment
required in renal failure

Special Points

Reversal:
irreversible binding - no reversal agent
dialysis with PMMA membranes works