Core pharmacology

Class Group

OXYTOCIC

Legacy Cicm Level

Level 3

Introduction

Ergot Alkaloids

Indications Uses

1. Prevention and treatment of PPH
2. Termination of pregnancy
3. Facilitate delivery of placenta

Main Action

Uterine contraction, mechanism unknown (likely serotonin mediated)

Adverse Effects Toxicity

1. Hypertension
2. Peripheral vasoconstriction
3. Headache

Absorption

IM often in combination with oxytocin

Distribution

Uterine contraction seen within minutes of IM and lasts 6 hours

Metabolism

Metabolized by liver and excreted in bile