Core pharmacology

Class Group

Antiplatelet

Legacy Cicm Level

-

Introduction

PDE3 inhibitor

Main Action

Platelet inhibition

Mechanism of action

Phosphodiesterase 5&3 inhibition in the platelet→ cAMP and intracellular Ca.
It reduces the platelet's ability to adhere to damaged vascular
endothelium by inhibiting
adenosine uptake, potentiates the effects of prostacyclin and interferes with adhesion more than aggregation. Also causes potent coronary vasodilatation

Adverse Effects Toxicity

Haemorrhage, may cause
hypotension,
thrombocytopenia and
myalgias. Dipyridamole can be incorporated into gall stones.

Metabolism

Undergoes hepatic conjugation
to glucuronide.

Excretion

Mainly excreted
as glucuronides in bile,5%
excreted in urine

Half-life

HL 10-12 hrs