Core pharmacology

Legacy Cicm Level

Level 3

Main Action

Cationic biguanide -strongly adsorbs to bacterial membranes causing leakage of small particles and precipitation of cytoplasmic proteins

Mechanism of action

Resistant to inactivation by blood and organic material
Low skin irritation

Antimicrobial Spectrum

Onset: Delayed

Duration:
Sustained residual activity

Resistance Mechanism

- Bacteria (G+ve>G-ve)
- Moderate fungal and viral activity
- Inhibits spore germination

Ineffective Against

Spores and prions
Hydrophilic viruses are less susceptible

Special Points

Can be combined with 70% alcohol
Preferred antiseptic for central venous access
Not absorbed orally

Route And Dose

1. Neurotoxic
2. Delayed effect
3. No direct spore activity