Core pharmacology

Class Group

Anticonvulsant

Legacy Cicm Level

-

Indications Uses

Anti-convulsant
Epilepsy
Schizophrenia
Trigeminal neuralgia

Mechanism of action

Inhibits voltage gate Na channels
- Diffuses intracellularly and becomes
ionized
- Inhibits Na influx and therefore inhibits
depolarization
- Neurons become less excitable

Absorption

100% Oral bioavailability

Protein binding

80% Protein binding,

Volume of distribution

Vd 1l/kg

Metabolism

Hepatic phase 1 and 2

Excretion

Renal

Half-life

T1/2b 24 hours