Level 1

Natural Colloid

1. Risk of Creutzfeldt Jakob Disease and Parvovirus B19 (Resistant to heat treatment)
2. Pulmonary oedema
3. Has been associated with myocardial depression
4. Contraindicated in TBI

Under normal circumstances 40% of albumin is intravascular and 60% is extravascular

Breakdown is predominantly by intracellular lysosome proteases under feedback control

Albumin normally has a T1/2 of 19 days

Colloid

1. Hypoproteinaemia
2. Shock
3. Burns
4. ARDS
5. Plasma exchange

- Heat treated human albumin
200ml bottles containing 200g/L. Straw coloured clear solution.
- Shelf life of 4 years
- Should be stored <30’C
- Heat treated at 60’C for 10 hours (pasteurized) and incubated at low pH
- Contains sodium chloride and water for injection
- 20% is hyperoncotic with approximately the equivalence of approximately 4x its volume in plasma

Albumin accounts for 70% of plasma oncotic pressure. Carrier of hormones, enzymes, Mg2+ and Ca2+, and acidic drugs.

CVS: Dependent on circulating volume status. Raised plasma oncotic pressure may lead to 3x the administered volume being dragged into the plasma within 15min.

pH 6.7-7.3
Osm 260

Na 100

Albumin 200gm/L (20gm in 100ml)

1. Volume replacement
2. Priming of extracorporeal circuits
3. Treatment of hypoalbuminaemic states
4. Replacement fluid during plasma exchange
5. Spontaneous bacterial peritonitis

- Heat treated human albumin
500ml bottles containing 10g albumin.
- Straw-coloured clear solution.
- Shelf life of 4 years
- Should be stored <30’C
- Heat treated at 60’C for 10 hours (pasteurized) and incubated at low pH
- Contains sodium chloride and water for injection
- 4% is iso-oncotic

Albumin accounts for 70% of plasma oncotic pressure. Carrier of hormones, enzymes and drugs.

CVS: Dependent on circulating volume status.

Na 140
Cl 128

Albumin 40gm/L (20gm in 500ml)

Fractionated Plasma Product