Pharmacopeia

Canonical comparison

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Compare candidate-facing canonical Pharmacopeia fields side by side. Isolated AI-draft proposals are never included.

2selected

Field	ROCURONIUM Neuromuscular · Neuromuscular · Level 1	CISATRACURIUM Neuromuscular · Neuromuscular · Level 1
Mechanism of action	ND-NMB acts as competitive antagonist → competes with ACh for nAChR binding → blocks cholinergic transmission → muscle relaxation (> 70% post-synaptic nAChR occupancy required to result in block) ND-NMB also inhibits pre-synaptic ACh receptors →prevents enhancement of ACh release → fade with repeated stimulation	ND-NMB acts as competitive antagonist → competes with ACh for nAChR binding → blocks cholinergic transmission → muscle relaxation (> 70% post-synaptic nAChR occupancy required to result in block) ND-NMB also inhibits pre-synaptic ACh receptors →prevents enhancement of ACh release → fade with repeated stimulation
Distribution	Doesn’t cross BBB	—
Protein binding	PB 10%	PB 15%
Volume of distribution	VD 0.2L/kg	VD 0.15L/kg
Metabolism	<5% Metabolism Hep	77% Hofmann degradation → laudanosine and quat. monoacrylates Minimal ester hydrolysis Inactive metabolites
Excretion	Renal: 30-40% Liver: 60%	Ren: 10-30% (laud.) Liver: (laudanosine)
Clearance	Pl cl: 3ml/kg/min	Pl cl 4-5ml/kg/min
Half-life	El t1/2: 90mins	El t1/2: 25mins
Adverse Effects Toxicity	HISTAMINE RELEASE - None EFFECT ON ANS - Can be vagolytic (↑HR) OTHER - Anaphylaxis - Pain on injection	HISTAMINE RELEASE - None VAGOLYSIS - None OTHER - Anaphylaxis
Chemical Pharmaceutics	Monoquaternary	Bisquaternary. 1 of 10 stereoisomers. In atrac (15% wt, 50% pot)
Class Group	Non-Depolarizing Aminosteroid	Non-Depolarizing Isoquinolone
Indications Uses	1. to facilitate tracheal intubation during routine and modified rapid sequence induction 2. for controlled ventilation.	to facilitate intubation and controlled ventilation
Introduction	Aminosteroid	Benzylisoquinolinium ester
Legacy Cicm Level	Level 1	Level 1
Onset Peak Duration	Int @ 100 – 120s RSI @ 60s Duration 35mins	Intubate @ 3 – 5min Duration 45mins
Presentation	Clear, colourless solution, 10mg/mL rocuronium bromide	Clear, 10mg in 5mL as cisatracurium besylate, stored at 4°C.
Route And Dose	ED95 0.3 mg/kg Int 0.6 mg/kg RSI 0.9 ~ 1.2 mg/kg Inf 9 – 12 mcg/kg/min	ED95 0.05 mg/kg Int 0.15 mg/kg Inf 1 – 2 mcg/kg/min
Special Points	Duration prolonged by: - ↓K ↓Ca ↑Mg - ↑pH ↑PaCO2 - ↓temp ↓protein Dehydration Reversible with sugammadex	Duration prolonged by: - ↓K ↓Ca ↑Mg - ↑pH ↑PaCO2 - ↓temp ↓protein Dehydration