Pharmacopeia
Master Compare
Compare candidate-facing canonical Pharmacopeia fields side by side. Isolated AI-draft proposals are never included.
| Field |
AMPHOTERICIN B
Anti-infectives · Anti-infectives · Level 3
|
GANCICLOVIR
Anti-infectives · Anti-infectives · Level 3
|
|---|---|---|
| Mechanism of action | Polyenes specifically target fungal membranes. They bind ergosterol, which is the principal sterol in fungal membranes as opposed to cholesterol found in host membranes. This interference creates a transmembrane channel and the resultant change in permeability allows leakage of intracellular components |
— |
| Absorption | only administered IV |
— |
| Distribution | Poor tissue penetration. Negligable CSF or urine penetration. |
— |
| Protein binding | Highly protein bound |
— |
| Metabolism | Metabolised by the liver |
— |
| Excretion | poorly characterized but does not accumulate in renal failure |
— |
| Adverse Effects Toxicity | Dose related nephrotoxicity |
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| Antimicrobial Spectrum | Broad antifungal cover including candida, Cryptococcus, aspergillus and zygomyces |
— |
| Class Group | Antifungal |
Antiviral |
| Introduction | Polyene |
— |
| Legacy Cicm Level | Level 3 |
Level 3 |