Syllabus · Current · V5 (2025) · Haematological and Immunological System

N1 · Physiology of Haematological System

N1.iv · Haemostasis, Coagulation & Fibrinolysis

Official V5 objective
Describe the process and regulation of haemostasis, coagulation and fibrinolysis.
7 SAQ topics 8 SAQ appearances 17 VIVA stations

Written examination

SAQ history

8 appearances
Outline the physiological processes that occur in a blood vessel after venipuncture (80% of marks). How are these altered by the administration of aspirin (20% of marks)?
66%
Outline the major clotting factors and steps in the haemostasis pathway (70% marks). Outline the mechanism of action of thrombolytics (30% marks).
80%
Haemostasis — Fibrinolysis
1 exam appearance
Describe the fibrinolytic pathway and identify areas of interaction with the coagulation pathway (80% of marks). List two anti-fibrinolytic agents and state their specific mechanism of action (20% of marks).
8%
(a) Outline the process of fibrinolysis including how it interacts with the coagulation system (80% of marks). (b) Describe the mechanism of action and adverse effects of alteplase (20% of marks).
3%
Describe the sequence of haemostatic events following injury to a blood vessel wall until clot stabilisation.
46%
Outline the sequence of haemostatic events after injury to a blood vessel wall (50% of marks). Discuss the role of naturally occurring anticoagulants in preventing clot formation in-vivo (50% of marks).
40%
Haemostasis — Platelets
1 exam appearance
Outline the role of platelets in blood clotting following an injury to a blood vessel.
40%
Outline the process of fibrinolysis (40% marks). Write short notes on the indications, mechanism of action, pharmacokinetics and side effects of tranexamic acid (60% marks).
30%

Oral examination

VIVA history

17 stations

Sources: objective text from the relevant CICM syllabus; historical SAQ and VIVA wording from CICM examiner reports.