D7.ii · Adrenergic Structure–Activity Relationships

No mapped SAQ history for this objective.

• 2018B · Day 2 · VIVA 2
  This station will explore your knowledge of Catecholamines. This is adrenaline (epinephrine). What are the important STRUCTURAL components? (Image removed from report.)
  90% successful
• 2013B · VIVA 5
  This Viva explored knowledge of the control of the heart rate. It assessed knowledge of the origin of the heart rate, its regulation, and catecholamines. Most candidates performed well. Anatomical location of the SA node, ionic currents related to the action potential, structure-activity of catecholamines and dobutamine pharmacokinetics were areas of weakness.
  82.4% successful
• 2008A · VIVA 5
  CH2 CH2 NH2 Candidates were expected to recognise ‘phenylethylamine’ and appreciate that it is the precursor molecule for the naturally occurring catecholamines. A brief overview of its structure activity relationships, particularly with respect to substitutions on the phenyl ring, β carbon and amine group (producing dopamine, adrenaline and noradrenaline) was expected. Questioning then progressed to discuss the pharmacology of noradrenaline in more detail. Changing questions, candidates were asked to provide a very brief overview of what the autonomic nervous system was before exploring the physiology of the valsalva manoeuvre in some detail. Syllabus: G3a2d, G3a2b and G3a1
  Pass rate not reported