Core pharmacology

Class Group

TOCOLYTIC

Legacy Cicm Level

Level 3 for Tocolysis

(NSAIDs Level 3 for Pain. Indomethacin Not included in that table)

Introduction

indole-acetic acid derivative

Indications Uses

early preterm labor (< 30 wk) or preterm labor associated with polyhydramnios

(Other NSAID uses)

Main Action

Decreased synthesis of PGE2 and PGF-2-alpha leading to decreased contraction of smooth muscle

Adverse Effects Toxicity

- Maternal A/E: GIT upsets, renal impairment, asthma

- Fetal A/E: constriction of ductus arteriosis, pulmonary hypertension, reversible decrease in renal function (oligohydramnios)

Absorption

Loading: 50-100 mg PR
Maintenance: 25-50mg PO Q6-8hrly