Core pharmacology

Class Group

Anticonvulsant

Legacy Cicm Level

Level 3

Indications Uses

Anti-convulsant
Epilepsy

Mechanism of action

Inhibits catabolism of γamino butyric acid(GABA) and inhibits voltage gated Na channels
- Increased [GABA] in neuronal junctions
- Increased Cl- conductance into neurons
- Neuronal hyperpolarization
- Increased threshold for depolarization
- Increased seizure threshold

Absorption

100% Oral bioavailability

Protein binding

90% Protein binding,

Volume of distribution

Vd 0.4l/kg

Metabolism

Hepatic β oxidation and conjugation

Excretion

Renal

Half-life

T1/2b 20 hours