Core pharmacology

Legacy Cicm Level

-

Main Action

Alkylation of micro-organism proteins or nucleic acids

Mechanism of action

Used for sterilization of equipment that cannot withstand high temperatures

Antimicrobial Spectrum

Onset: 2.4% glutaraldehyde achieve disinfection in 45 minutes

Resistance Mechanism

- Bacteria (G+ve and –ve and acid fast)
- Spores
- Viruses
- Fungi

Ineffective Against

Prions

Special Points

Used to sterilize fiber optic endoscopes and respiratory therapy equipment

Route And Dose

1. Once activated have a shelf life of 14 days
2. Failure of activity may occur due to excessive dilution or exposure to organic material (frequently reused)
3. Irritating to eyes and respiratory mucosa
4. Slow activity