Core pharmacology

Class Group

Antidepressant - Selective serotonin reuptake inhibitors

Legacy Cicm Level

Level 3

Mechanism of action

Inhibition of SERT transporter increases synaptic 5-HT. No effect on NET

Adverse Effects Toxicity

Serotonin A/E (shared by all AD):
- Insomnia/somnolence
- N/V/D
- Sexual- low libido, impotence
Initial suicidality

Absorption

50:50 racemic mixture
Well absorbed

Metabolism

Hepatic metabolism

Excretion

Does require dose adjustment in renal failure for metabolites